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Article

Genetic polymorphisms in sigma-1 receptor and apolipoprotein E interact to influence the severity of Alzheimer's disease.

Current Alzheimer research - 1 Nov 2011

Huang Yue, Zheng Lan, Halliday Glenda, Dobson-Stone Carol, Wang Ying, Tang Hui-Dong, Cao Li, Deng Yu-Lei, Wang Gang, Zhang Yu-Mei, Wang Jian-Hua, Hallupp Marianne, Kwok John, Chen Sheng-Di

Abstract excerpt

Apolipoprotein E (APOE) ε4 allele and sigma-1 receptor (SIGMAR1) c.5C (Q2P) polymorphisms have been acknowledged as risk factors for developing Alzheimer's disease (AD). However, whether these polymorphisms influence the disease process is unclear. Therefore, two cohorts with a clinical diagnosis of AD were recruited, a postmortem confirmed Australian cohort (82 cases) from the Australian Brain Bank Network, and...

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Identifiers

PMID: 21605063
DOI: 10.2174/156720511797633232

Genes

APOE
SIGMAR1

Variants

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