Article
Filaggrin deficient mice have a lower threshold for cutaneous allergen sensitization but do not develop spontaneous skin inflammation or atopy
2020-09-11
Abstract excerpt
Defects of filaggrin (FLG) compromise epidermal barrier function and represent an important known genetic risk factor for atopic dermatitis (AD), but also for systemic atopy, including allergic sensitization and asthma. The flaky tail mouse model, widely used to address mechanisms of atopy induction by barrier-defective skin, harbors two mutations that affect the skin barrier, the mutation Flg ft , resulting in n...
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Identifiers and source
- Literature Corpus work
- 6950891c-163a-5e8f-b20c-0b58aeb1c1f2
- DOI
- 10.1101/2020.09.11.293688