Article
A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis.
The Journal of allergy and clinical immunology - 1 Nov 2013
Sasaki Takashi, Shiohama Aiko, Kubo Akiharu, Kawasaki Hiroshi, Ishida-Yamamoto Akemi, Yamada Taketo, Hachiya Takayuki, Shimizu Atsushi, Okano Hideyuki, Kudoh Jun, Amagai Masayuki
Abstract excerpt
BACKGROUND: Flaky tail (ma/ma Flg(ft/ft)) mice have a frameshift mutation in the filaggrin (Flg(ft)) gene and are widely used as a model of human atopic dermatitis associated with FLG mutations. These mice possess another recessive hair mutation, matted (ma), and develop spontaneous dermatitis under specific pathogen-free conditions, whereas genetically engineered Flg(-/-) mice do not. OBJECTIVE: We identified...
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