Article
Flaky tail mouse denotes human atopic dermatitis in the steady state and by topical application with Dermatophagoides pteronyssinus extract.
The American journal of pathology - 1 May 2010
Moniaga Catharina Sagita, Egawa Gyohei, Kawasaki Hiroshi, Hara-Chikuma Mariko, Honda Tetsuya, Tanizaki Hideaki, Nakajima Saeko, Otsuka Atsushi, Matsuoka Hiroyuki, Kubo Akiharu, Sakabe Jun-ichi, Tokura Yoshiki, Miyachi Yoshiki, Amagai Masayuki, Kabashima Kenji
Abstract excerpt
The barrier abnormality, a loss-of-function mutation in the gene encoding filaggrin (FLG), which is linked to the incidence of atopic dermatitis (AD), is a recently discovered but important factor in the pathogenesis of AD. Flaky tail (Flg(ft)) mice, essentially deficient in filaggrin, have been used to investigate the role of filaggrin on AD. However, the relevancy of Flg(ft) mice to human AD needs to be...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.