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Article

Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity.

The Journal of allergy and clinical immunology - 1 Feb 2016

Saunders Sean P, Moran Tara, Floudas Achilleas, Wurlod Felicity, Kaszlikowska Agnieszka, Salimi Maryam, Quinn Emma M, Oliphant Christopher J, Núñez Gabriel, McManus Ross, Hams Emily, Irvine Alan D, McKenzie Andrew N J, Ogg Graham S, Fallon Padraic G

Abstract excerpt

BACKGROUND: Atopic dermatitis (AD) is an inflammatory skin condition that can occur in early life, predisposing to asthma development in a phenomenon known as the atopic march. Although genetic and environmental factors are known to contribute to AD and asthma, the mechanisms underlying the atopic march remain poorly understood. Filaggrin loss-of-function mutations are a major genetic predisposer for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26299987
DOI: 10.1016/j.jaci.2015.06.045
PMCID: PMC4735016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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