Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.

doi:10.1016/j.jaci.2013.08.046

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Article

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.

The Journal of allergy and clinical immunology - 1 Nov 2013

Saunders Sean P, Goh Christabelle S M, Brown Sara J, Palmer Colin N A, Porter Rebecca M, Cole Christian, Campbell Linda E, Gierlinski Marek, Barton Geoffrey J, Schneider Georg, Balmain Allan, Prescott Alan R, Weidinger Stephan, Baurecht Hansjörg, Kabesch Michael, Gieger Christian, Lee Young-Ae, Tavendale Roger, Mukhopadhyay Somnath, Turner Stephen W, Madhok Vishnu B, Sullivan Frank M, Relton Caroline, Burn John, Meggitt Simon, Smith Catherine H, Allen Michael A, Barker Jonathan N W N, Reynolds Nick J, Cordell Heather J, Irvine Alan D, McLean W H Irwin, Sandilands Aileen, Fallon Padraic G

Abstract excerpt

BACKGROUND: Atopic dermatitis (AD) is a major inflammatory condition of the skin caused by inherited skin barrier deficiency, with mutations in the filaggrin gene predisposing to development of AD. Support for barrier deficiency initiating AD came from flaky tail mice, which have a frameshift mutation in Flg and also carry an unknown gene, matted, causing a matted hair phenotype. OBJECTIVE: We sought to identify...

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PMID: 24084074
DOI: 10.1016/j.jaci.2013.08.046
PMCID: PMC3834151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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