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Article

One remarkable molecule: filaggrin.

The Journal of investigative dermatology - 1 Mar 2012

Brown Sara J, McLean W H Irwin

Abstract excerpt

The discovery, in 2006, that loss-of-function mutations in the filaggrin (FLG) gene are the cause of ichthyosis vulgaris-the most common disorder of keratinization-and also a strong genetic risk factor for atopic eczema, marked a significant breakthrough in the understanding of eczema pathogenesis. Subsequent investigations of the role of FLG-null mutations have identified a series of significant associations...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22158554
DOI: 10.1038/jid.2011.393
PMCID: PMC3378480

Genes

FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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One remarkable molecule: filaggrin.PMID 22158554Read ↗

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Filaggrin failure - from ichthyosis vulgaris to atopic eczema and beyondSemantic proximity Read ↗

Filaggrin in the frontline: role in skin barrier function and diseaseSemantic proximity Read ↗

Filaggrin gene defects and the risk of developing allergic disorders.Semantic proximity Read ↗

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