Article

Probing PAC1 receptor activation across species with an engineered sensor

2024-02-07

Abstract excerpt

Class-B1 G protein-coupled receptors (GPCRs) are an important family of clinically relevant drug targets that remain difficult to investigate via high-throughput screening and in animal models. Here, we engineered PAClight1 P78A , a novel genetically-encoded sensor based on a class-B1 GPCR (the human PAC1 receptor, hmPAC1R) endowed with high dynamic range (ΔF/F 0 = 1100%), excellent ligand selectivity and rapid...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6937d8b6-edb8-5eaf-8542-622d883d9d70
DOI: 10.1101/2024.02.06.579048

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Probing PAC1 receptor activation across species with an engineered sensorDOI 10.1101/2024.02.06.579048Read

[G protein-coupled receptors in the spot light].Semantic proximity Read

Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolutionSemantic proximity Read

Reversible Antagonism of Dopamine D1 Receptor using a Photoswitchable Remotely Tethered LigandSemantic proximity Read

A conserved and druggable pocket in class B G protein coupled receptors for orally active small molecule agonistsSemantic proximity Read

Direct interrogation of context-dependent GPCR activity with a universal biosensor platformSemantic proximity Read

Tuning up the right signal: chemical and genetic approaches to study GPCR functionsSemantic proximity Read

A Scalable, Multiplexed Assay for Decoding Receptor-Ligand InteractionsSemantic proximity Read

Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transportersSemantic proximity Read

Cancer-Related Somatic Mutations in Transmembrane Helices Alter Adenosine A1 Receptor Pharmacology.Semantic proximity Read

Signal profiling of the β1AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β1AR and β2AR.Semantic proximity Read

An expanded neurogenetic toolkit to decode olfaction in the African malaria mosquito Anopheles gambiaeSemantic proximity Read

GPCR expression in tissues and cells: Are the optimal receptors being used as drug targets?Semantic proximity Read