Article

A conserved and druggable pocket in class B G protein coupled receptors for orally active small molecule agonists

2023-06-08

Abstract excerpt

Class B G protein-coupled receptors (GPCRs), including glucagon-like receptor 1 (GLP-1R) and parathyroid hormone receptor 1 (PTH1R), are peptide hormone receptors and important drug targets. Injectable peptide drugs targeting class B GPCRs have been developed for the treatment of many diseases, including type 2 diabetes, obesity, and osteoporosis, but orally available small molecule drugs are hotly pursued in the...

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Literature Corpus work: 57cf5cf9-9a52-55ad-b4bb-7341004d940f
DOI: 10.1101/2023.06.08.544171

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