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Reversible Antagonism of Dopamine D1 Receptor using a Photoswitchable Remotely Tethered Ligand

2025-06-15

Abstract excerpt

<h4>ABSTRACT</h4> Dopamine D1 receptor (D1R) plays key roles in health and disease. D1R is broadly expressed throughout the brain and body and is dynamically activated in response to endogenous dopamine, making it difficult to target this receptor with sufficient precision. We previously developed a robust light-activatable, tetherable agonist for D1R, wherein a temporally precise photo-switch (the P compound) bi...

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Literature Corpus work
c161a714-673f-5bd9-8731-6e8bc43acdb9
DOI
10.1101/2025.06.10.658926
Open publication

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Reversible Antagonism of Dopamine D1 Receptor using a Photoswitchable Remotely Tethered LigandDOI 10.1101/2025.06.10.658926
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