Article

Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution

2023-02-16

Abstract excerpt

The glucagon-like peptide-1 receptor (GLP1R) is a broadly expressed target of peptide hormones with essential roles in energy and glucose homeostasis, as well as of the blockbuster weight-loss drugs semaglutide and liraglutide. Despite its large clinical relevance, tools to investigate the precise activation dynamics of this receptor with high spatiotemporal resolution are limited. Here we introduce a novel geneti...

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Literature Corpus work: 68627d3f-7dad-5929-9257-e201910922d4
DOI: 10.1101/2023.02.14.528498

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