Article

An ATM/Wip1-dependent timer controls the minimal duration of a DNA-damage mediated cell cycle arrest

2016-03-02

Abstract excerpt

After DNA damage, the cell cycle is arrested to avoid propagation of mutations. In G2 phase, the arrest is initiated by ATM/ATR-dependent signalling that blocks mitosis-promoting kinases as Plk1. Interestingly, Plk1 can counteract ATR-dependent signalling and is required for eventual resumption of the cell cycle. However, what determines when Plk1 activity can resume remains unclear. Here we use FRET-based reporte...

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Literature Corpus work: 692b22e3-28b0-568f-83c8-e1843adfafc1
DOI: 10.1101/042119

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