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Article

Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B.

Molecular and cellular biology - 1 Apr 2007

Geng Liyi, Zhang Xiaoshan, Zheng Shu, Legerski Randy J

Abstract excerpt

Artemis is a phospho-protein that has been shown to have roles in V(D)J recombination, nonhomologous end-joining of double-strand breaks, and regulation of the DNA damage-induced G(2)/M cell cycle checkpoint. Here, we have identified four sites in Artemis that are phosphorylated in response to ionizing radiation (IR) and show that ATM is the major kinase responsible for these modifications. Two of the sites, S534...

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Share to Ataxia Telangiectasia Mutated Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17242184
DOI: 10.1128/MCB.02072-06
PMCID: PMC1899901

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B.PMID 17242184Read ↗

Artemis Is a Phosphorylation Target of ATM and ATR and Is Involved in the G2/M DNA Damage Checkpoint ResponseSemantic proximity Read ↗

Ataxia‐telangiectasia‐mutated dependent phosphorylation of Artemis in response to DNA damageSemantic proximity Read ↗

Phosphorylation of Artemis following irradiation‐induced DNA damageSemantic proximity Read ↗

A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.Semantic proximity Read ↗

Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progressionSemantic proximity Read ↗

ATM: the product of the gene mutated in ataxia-telangiectasia.Semantic proximity Read ↗

Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repairSemantic proximity Read ↗

Multiple roles of ATM in monitoring and maintaining DNA integritySemantic proximity Read ↗

Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity.Semantic proximity Read ↗

Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycleSemantic proximity Read ↗

Radiation-induced delayed cell death in a hypomorphic Artemis cell line.Semantic proximity Read ↗

ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responsesSemantic proximity Read ↗

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