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Article

Modelling the onset of senescence at the G1/S cell cycle checkpoint.

BMC genomics - 1 Jan 2014

Mombach José C M, Bugs Cristhian A, Chaouiya Claudine

Abstract excerpt

BACKGROUND: DNA damage (single or double-strand breaks) triggers adapted cellular responses. These responses are elicited through signalling pathways, which activate cell cycle checkpoints and basically lead to three cellular fates: cycle arrest promoting DNA repair, senescence (permanent arrest) or cell death. Cellular senescence is known for having a tumour-suppressive function and its regulation arouses a...

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Identifiers

PMID: 25573782
DOI: 10.1186/1471-2164-15-S7-S7
PMCID: PMC4243082

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ATM
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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