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Article

WIP1 mutations suppress DNA damage triggered bypass of the mitotic timer.

The EMBO journal - 1 Aug 2025

Sobajima Tomoaki, Fulcher Luke J, Batley Caleb, Alsop Susanna J, Veakins Jonah, Barr Francis A

Abstract excerpt

Prolonged mitosis results in the destruction of MDM2, initiating a p53-dependent G1 cell-cycle arrest in the absence of DNA damage. Here, we investigate how DNA damage earlier in the cell cycle affects this mitotic-timer response. We find that G2-DNA damage triggers highly penetrant bypass of mitosis and of the mitotic timer, generating tetraploid cells arrested in G1. Collapse of G2 to G1 after DNA damage is...

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Share to DNA Damage
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Phosphatase 2C

Share to Proto-Oncogene Proteins c-mdm2

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 40551011
DOI: 10.1038/s44318-025-00495-0
PMCID: PMC12316910

Genes

MDM2
CDK2
PPM1D

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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