Article
Polo-like kinase 1 mediates BRCA1 phosphorylation and recruitment at DNA double-strand breaks.
Oncotarget - 19 Jan 2016
Chabalier-Taste Corinne, Brichese Laetitia, Racca Carine, Canitrot Yvan, Calsou Patrick, Larminat Florence
Abstract excerpt
Accurate repair of DNA double-strand breaks (DSB) caused during DNA replication and by exogenous stresses is critical for the maintenance of genomic integrity. There is growing evidence that the Polo-like kinase 1 (Plk1) that plays a number of pivotal roles in cell proliferation can directly participate in regulation of DSB repair. In this study, we show that Plk1 regulates BRCA1, a key mediator protein required...
Topics
- BRCA1 Protein
- Cell Cycle Proteins
- Cell Line, Tumor
- Cell Proliferation
- DNA
- DNA Breaks, Double-Stranded
- DNA Repair
- DNA Replication
- DNA-Binding Proteins
- HeLa Cells
- Homologous Recombination