Article

The proto-oncogene DEK regulates neuronal excitability and tau accumulation in Alzheimer’s disease vulnerable neurons

2022-05-15

Abstract excerpt

<h4>SUMMARY</h4> Neurons from layer II of the entorhinal cortex (ECII) are the first to accumulate tau protein aggregates and degenerate during prodromal Alzheimer’s disease. Here, we use a data-driven functional genomics approach to model ECII neurons in silico and identify the proto-oncogene DEK as a potential driver of tau pathology. By modulating DEK levels in EC neurons in vitro and in vivo , we first val...

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Literature Corpus work: 692af54c-43dc-5ab1-b91c-119bb40b7f49
DOI: 10.1101/2022.05.14.491965

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