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Article

A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer’s disease vulnerable neurons

11 Mar 2024

Abstract excerpt

Neurons from layer II of the entorhinal cortex (ECII) are the first to accumulate tau protein aggregates and degenerate during prodromal Alzheimer's disease. Gaining insight into the molecular mechanisms underlying this vulnerability will help reveal genes and pathways at play during incipient stages of the disease. Here, we use a data-driven functional genomics approach to model ECII neurons in silico and...

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PMID: 38462574
DOI: 10.1093/brain/awae051

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