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Telomere Maintenance Mechanisms in Cancer

3 May 2018

Abstract excerpt

Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere shortening, an inevitable process due to successive cell divisions. In most tumour cells, telomere length (TL) is maintained by reactivation of telomerase, while a small part acquires immortality through the telomerase-independent alternative lengthening of telomeres (ALT) mechanism. In the last years, a great amount of data was...

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PMID: 29751586
DOI: 10.3390/genes9050241

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