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Genomic, Microbial and Immunological Microenvironment of Colorectal Polyps

6 Jul 2021

Abstract excerpt

Colorectal cancer (CRC) develops from pre-cancerous cellular lesions in the gut epithelium, known as polyps. Polyps themselves arise through the accumulation of mutations that disrupt the function of key tumour suppressor genes, activate proto-oncogenes and allow proliferation in an environment where immune control has been compromised. Consequently, colonoscopic surveillance and polypectomy are central pillars...

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PMID: 34298598
DOI: 10.3390/cancers13143382

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