Article

Dysbiosis in pre-cancerous mucosa may drive immune dysfunction – a study of immune system: microbiota interaction in familial adenomatous polyposis

2021-05-13

Abstract excerpt

<h4>Objectives</h4> Familial adenomatous polyposis (FAP) is a condition caused by a constitutional pathogenic variant of the adenomatous polyposis coli ( APC ) gene that results in intestinal adenoma formation and colorectal cancer (CRC), necessitating pre-emptive colectomy. We sought to examine interaction between the mucosal immune system and commensal bacteria in FAP to test for immune dysfunction that might ac...

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Literature Corpus work: 89d33cdf-c08d-5a88-83d5-9ed38c51cad1
DOI: 10.1101/2021.05.05.21256687

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