Article

Identification of PS1/gamma-secretase and glutamate transporter GLT-1 interaction sites

2023-05-30

Abstract excerpt

The recently discovered interaction between Presenilin 1 (PS1), a catalytic subunit of γ-secretase responsible for generating amyloid-β (Aβ) peptides, and GLT-1, a major glutamate transporter in the brain (EAAT2) provides a mechanistic link between these two key factors involved in Alzheimer’s disease (AD) pathology. Modulating this interaction can be crucial to understand the consequence of such crosstalk in AD c...

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Literature Corpus work: 68a8c6f0-f572-5c36-b1f3-dd79a949e0c1
DOI: 10.1101/2023.05.30.542955

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