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Article

Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio.

PloS one - 18 Nov 2009

Uemura Kengo, Lill Christina M, Li Xuejing, Peters Jessica A, Ivanov Alexander, Fan Zhanyun, DeStrooper Bart, Bacskai Brian J, Hyman Bradley T, Berezovska Oksana

Abstract excerpt

BACKGROUND: Presenilin 1(PS1) is the catalytic subunit of gamma-secretase, the enzyme responsible for the Abeta C-terminal cleavage site, which results in the production of Abeta peptides of various lengths. Production of longer forms of the Abeta peptide occur in patients with autosomal dominant...

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Source

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Identifiers

PMID: 19924286
DOI: 10.1371/journal.pone.0007893
PMCID: PMC2773935

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19924286-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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