Article

PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer’s disease

2023-11-07

Abstract excerpt

The recently discovered interaction between presenilin 1 (PS1), a catalytic subunit of γ-secretase responsible for the generation of amyloid-β(Aβ) peptides, and GLT-1, the major glutamate transporter in the brain (EAAT2 in the human) may provide a mechanistic link between two important pathological aspects of Alzheimer’s disease (AD): abnormal Aβoccurrence and neuronal network hyperactivity. In the current study,...

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Literature Corpus work: 42db369e-7abc-54a6-80be-6a96664d27e7
DOI: 10.21203/rs.3.rs-3495211/v1

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