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Article

Sequential conformational changes in transmembrane domains of presenilin 1 in Aβ42 downregulation.

Journal of biochemistry - 11 Oct 2021

Cai Tetsuo, Tomita Taisuke

Abstract excerpt

Alzheimer disease (AD) is the most common neurodegenerative disease worldwide. AD is pathologically characterized by the deposition of senile plaques in the brain, which are composed of an amyloid-β peptide (Aβ) that is produced through the multistep cleavage of amyloid precursor protein (APP) by γ-secretase. γ-Secretase is a membrane protein complex, which includes its catalytic subunit presenilin 1 (PS1)....

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PMID: 33739423
DOI: 10.1093/jb/mvab033

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