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Article

PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer's disease.

Acta neuropathologica communications - 21 Oct 2024

Perrin Florian, Anderson Lauren C, Mitchell Shane P C, Sinha Priyanka, Turchyna Yuliia, Maesako Masato, Houser Mei C Q, Zhang Can, Wagner Steven L, Tanzi Rudolph E, Berezovska Oksana

Abstract excerpt

The recently discovered interaction between presenilin 1 (PS1), a subunit of γ-secretase involved in amyloid-β (Aβ) peptide production, and GLT-1, the major brain glutamate transporter (EAAT2 in the human), may link two pathological aspects of Alzheimer's disease: abnormal Aβ occurrence and neuronal network hyperactivity. In the current study, we employed a FRET-based fluorescence lifetime imaging microscopy...

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Identifiers

PMID: 39434170
DOI: 10.1186/s40478-024-01876-y
PMCID: PMC11492509

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