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Article

Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase.

Molecular and cellular neurosciences - 1 Jun 2009

Herl Lauren, Thomas Anne V, Lill Christina M, Banks Mary, Deng Amy, Jones Phill B, Spoelgen Robert, Hyman Bradley T, Berezovska Oksana

Abstract excerpt

Alzheimer's disease is characterized by accumulation of toxic beta-amyloid (Abeta) in the brain and neuronal death. Several mutations in presenilin (PS1) and beta-amyloid precursor protein (APP) associate with an increased Abeta(42/40) ratio. Abeta(42), a highly fibrillogenic species, is believed to drive Abeta aggregation. Factors shifting gamma-secretase cleavage of APP to produce Abeta(42) are unclear. We...

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Identifiers

PMID: 19281847
DOI: 10.1016/j.mcn.2009.02.008
PMCID: PMC2732195

Genes

APP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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