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NOTCH Signaling Pathway: Occurrence, Mechanism, and NOTCH-Directed Therapy for the Management of Cancer

5 Oct 2023

Abstract excerpt

It is now well understood that many signaling pathways are vital in carrying out and controlling essential pro-survival and pro-growth cellular functions. The NOTCH signaling pathway, a highly conserved evolutionary signaling pathway, has been thoroughly studied since the discovery of NOTCH phenotypes about 100 years ago in Drosophila melanogaster . Abnormal NOTCH signaling has been linked to the pathophysiology...

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PMID: 37797218
DOI: 10.1089/cbr.2023.0023

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