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Article

Precision medicine for human cancers with Notch signaling dysregulation (Review)

4 Dec 2019

Abstract excerpt

NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that transduce juxtacrine signals of the delta‑like canonical Notch ligand (DLL)1, DLL3, DLL4, jagged canonical Notch ligand (JAG)1 and JAG2. Canonical Notch signaling activates the transcription of BMI1 proto‑oncogene polycomb ring finger, cyclin D1, CD44, cyclin dependent kinase inhibitor 1A, hes family bHLH transcription factor 1, hes related family...

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Identifiers

PMID: 31894255
DOI: 10.3892/ijmm.2019.4418

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