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Article

Notch Signaling in Cancer: Rationale and Strategies for Targeting

10 Jul 2015

Abstract excerpt

The Notch signaling pathway is a highly conserved system that controls embryonic cell fate decisions and the maintenance of adult stem cells through affecting communication between adjacent cells. The pathway is linked to the development of various cancers owing to increased cell proliferation and tumor blood perfusion in addition to inhibition of apoptosis. Pharmaceutical agents that suppress overactive Notch...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26239151
DOI: 10.2174/156800961505150710113353

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