Article

Whole genome sequencing of ovarian granulosa cell tumors reveals tumor heterogeneity and a high-grade TP53-specific subgroup

2020-02-23

Abstract excerpt

Adult granulosa cell tumors (AGCTs) harbor a somatic FOXL2 c.402C>G mutation in ∼95% of cases and are mainly surgically removed due to limited systemic treatment effect. In this study, potentially targetable genomic alterations in AGCTs were investigated by whole genome sequencing on 46 tumor samples and matched normal DNA. Copy number variant (CNV) analysis confirmed gain of chromosome 12 and 14, and loss of 22....

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Literature Corpus work: 68645162-9411-569a-aa4e-d815211862c8
DOI: 10.1101/2020.02.21.20025007

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