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Whole-exome sequencing reveals potential germline and somatic mutations in 60 malignant ovarian germ cell tumors†.

Biology of reproduction - 2 Jul 2021

Chen Juan, Li Yan, Wu Jianlei, Liu Yakun, Kang Shan

Abstract excerpt

Malignant ovarian germ cell tumors (MOGCTs) are rare and heterogeneous ovary tumors. We aimed to identify potential germline mutations and somatic mutations in MOGCTs by whole-exome sequencing. The peripheral blood and tumor samples from these patients were used to identify germline mutations and somatic mutations, respectively. For those genes with copy number alterations (deletion and duplication region),...

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PMID: 33739378
DOI: 10.1093/biolre/ioab052

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