Integrated Analysis of Ovarian Juvenile Granulosa Cell Tumors Reveals Distinct Epigenetic Signatures and Recurrent TERT Rearrangements.

doi:10.1158/1078-0432.CCR-21-3394

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Integrated Analysis of Ovarian Juvenile Granulosa Cell Tumors Reveals Distinct Epigenetic Signatures and Recurrent TERT Rearrangements.

Clinical cancer research : an official journal of the American Association for Cancer Research - 14 Apr 2022

Vougiouklakis Theodore, Zhu Kelsey, Vasudevaraja Varshini, Serrano Jonathan, Shen Guomiao, Linn Rebecca L, Feng Xiaojun, Chiang Sarah, Barroeta Julieta E, Thomas Kristen M, Schwartz Lauren E, Shukla Pratibha S, Malpica Anais, Oliva Esther, Cotzia Paolo, DeLair Deborah F, Snuderl Matija, Jour George

Abstract excerpt

PURPOSE: Adult granulosa cell tumor (AGCT) is characterized by the somatic FOXL2 p.C134W mutation, and recurrences have been associated with TERT promoter and KMT2D-truncating mutations. Conversely, the molecular underpinnings of the rare juvenile granulosa cell tumor (JGCT) have not been well elucidated. To this end, we applied a tumor-only integrated approach to investigate the genomic, transcriptomic, and...

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PMID: 35031544
DOI: 10.1158/1078-0432.CCR-21-3394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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