Article
Mutational Landscape of Ovarian Adult Granulosa Cell Tumors from Whole Exome and Targeted TERT Promoter Sequencing.
Molecular cancer research : MCR - 1 Jan 2019
Alexiadis Maria, Rowley Simone M, Chu Simon, Leung Dilys T H, Stewart Colin J R, Amarasinghe Kaushalya C, Campbell Ian G, Fuller Peter J
Abstract excerpt
Adult granulosa cell tumor (aGCT), the most common malignant ovarian sex cord-stromal tumor, is characterized by the forkhead transcription factor FOXL2 p.C134W somatic mutation. Late recurrences are relatively common but the molecular mechanisms of relapse or aggressive behavior are not known. The mutational landscape of FOXL2 p.C134W mutation-positive tumors (n = 22) was determined using whole-exome sequencing...
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