Article
Mutation of FOXL2 in granulosa-cell tumors of the ovary.
The New England journal of medicine - 25 Jun 2009
Shah Sohrab P, Köbel Martin, Senz Janine, Morin Ryan D, Clarke Blaise A, Wiegand Kimberly C, Leung Gillian, Zayed Abdalnasser, Mehl Erika, Kalloger Steve E, Sun Mark, Giuliany Ryan, Yorida Erika, Jones Steven, Varhol Richard, Swenerton Kenneth D, Miller Dianne, Clement Philip B, Crane Colleen, Madore Jason, Provencher Diane, Leung Peter, DeFazio Anna, Khattra Jaswinder, Turashvili Gulisa, Zhao Yongjun, Zeng Thomas, Glover J N Mark, Vanderhyden Barbara, Zhao Chengquan, Parkinson Christine A, Jimenez-Linan Mercedes, Bowtell David D L, Mes-Masson Anne-Marie, Brenton James D, Aparicio Samuel A, Boyd Niki, Hirst Martin, Gilks C Blake, Marra Marco, Huntsman David G
Abstract excerpt
BACKGROUND: Granulosa-cell tumors (GCTs) are the most common type of malignant ovarian sex cord-stromal tumor (SCST). The pathogenesis of these tumors is unknown. Moreover, their histopathological diagnosis can be challenging, and there is no curative treatment beyond surgery. METHODS: We analyzed four adult-type GCTs using whole-transcriptome paired-end RNA sequencing. We identified putative GCT-specific...
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