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Article

Adult-type granulosa cell tumor of the ovary: a FOXL2-centric disease.

The journal of pathology. Clinical research - 1 May 2021

Pilsworth Jessica A, Cochrane Dawn R, Neilson Samantha J, Moussavi Bahar H, Lai Daniel, Munzur Aslı D, Senz Janine, Wang Yi Kan, Zareian Sina, Bashashati Ali, Wong Adele, Keul Jacqueline, Staebler Annette, van Meurs Hannah S, Horlings Hugo M, Kommoss Stefan, Kommoss Friedrich, Oliva Esther, Färkkilä Anniina Em, Gilks Blake, Huntsman David G

Abstract excerpt

Adult-type granulosa cell tumors (aGCTs) account for 90% of malignant ovarian sex cord-stromal tumors and 2-5% of all ovarian cancers. These tumors are usually diagnosed at an early stage and are treated with surgery. However, one-third of patients relapse between 4 and 8 years after initial diagnosis, and there are currently no effective treatments other than surgery for these relapsed patients. As the majority...

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PMID: 33428330
DOI: 10.1002/cjp2.198
PMCID: PMC8072996

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Adult-type granulosa cell tumor of the ovary: a FOXL2-centric disease.PMID 33428330Read ↗

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