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Article

Landscape of potential germline pathogenic variants in select cancer susceptibility genes in patients with adult-type ovarian granulosa cell tumors.

Cancer medicine - 1 Jun 2024

Summey Rebekah M, Gornstein Erica, Decker Brennan, Dougherty Kali C, Rader Janet S, Hopp Elizabeth

Abstract excerpt

OBJECTIVE: The objective of this study was to assess the frequency of potential germline pathogenic variants that may contribute to risk of development of adult granulosa cell tumors (AGCT) given the paucity of germline testing guidelines for these patients. METHODS: This was a retrospective cross-sectional study analyzing comprehensive genomic profiling (CGP) results of AGCT with the FOXL2 p.C134W mutation...

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Source

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Identifiers

PMID: 38898688
DOI: 10.1002/cam4.7340
PMCID: PMC11187164

Genes

CHEK2
FOXL2
ATM
BRCA1
BRCA2
PALB2
PMS2
RAD51C
RAD51D

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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