Article

UTX inhibition suppresses proliferation and promotes apoptosis in patient-derived glioblastoma stem cells by modulating periostin expression

2022-12-29

Abstract excerpt

<title>Abstract</title> <p>Glioblastoma stem cells (GSCs) link tightly to glioblastoma (GBM) development, progression, therapeutic resistance and recurrence, suggesting GSCs as a novel target for drug discovery. UTX, a histone H3K27 demethylase, participates in regulating multiple cancer types. However, less is known about the function of UTX in GBM, let alone in GSCs. Our study aims to investigate the role and r...

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Literature Corpus work: 682c6905-4053-5c70-85c7-dbc9f5be03a2
DOI: 10.21203/rs.3.rs-2082131/v2

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