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Article

CCN1 Promotes Mesenchymal Phenotype Transition Through Activating NF-κB Signaling Pathway Regulated by S100A8 in Glioma Stem Cells.

CNS neuroscience & therapeutics - 1 Dec 2024

Guo Xing, Guo Shuhua, Tian Feng, Gao Zijie, Fan Yang, Wang Chuanxin, Xu Shuo

Abstract excerpt

BACKGROUND: The presence of glioma stem cells (GSCs) and the occurrence of mesenchymal phenotype transition contribute to the miserable prognosis of glioblastoma (GBM). Cellular communication network factor 1 (CCN1) is upregulated within various malignancies and associated with cancer development and progression, while the implications of CCN1 in the phenotype transition and tumorigenicity of GSCs remain unclear....

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Identifiers

PMID: 39659236
DOI: 10.1111/cns.70128
PMCID: PMC11632201

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