Article
PBX3/MEK/ERK1/2/LIN28/let-7b positive feedback loop enhances mesenchymal phenotype to promote glioblastoma migration and invasion.
Journal of experimental & clinical cancer research : CR - 17 Jul 2018
Xu Xiupeng, Bao Zhongyuan, Liu Yinlong, Jiang Kuan, Zhi Tongle, Wang Dong, Fan Liang, Liu Ning, Ji Jing
Abstract excerpt
BACKGROUND: Brain invasion by glioblastoma (GBM) determines recurrence and prognosis in patients, which is, in part, attributed to increased mesenchymal transition. Here, we report evidence favoring such a role for the Pre-B-cell leukemia homebox (PBX) family member PBX3. METHODS: Western blot, immunohistochemistry, qRT-PCR and datasets mining were used to determined proteins or genes expression levels....
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