Article

SOX21 Suppresses Glioblastoma Growth by Repressing AP-1 Activity

2024-07-06

Abstract excerpt

<h4>Background</h4> Treatment-resistant glioblastoma stem cells (GSCs) drive glioblastoma (GBM) growth and recurrence. Thus, targeting the molecular machinery that sustains GSCs in an undifferentiated and self-renewing state is a promising therapeutic strategy. The transcription factor SOX21 effectively suppresses the tumorigenic capacity of GSCs. However, the mechanism by which SOX21 impedes GSC features is unkn...

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Literature Corpus work: e414e695-9d32-5037-a302-d33ccea6c2e5
DOI: 10.1101/2024.07.05.601643

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