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Periostin-mediated activation of NF-κB signaling promotes tumor progression and chemoresistance in glioblastoma

22 Apr 2025

Abstract excerpt

Glioblastoma (GBM) is the most aggressive form of diffuse glioma, characterized by high lethality. Temozolomide (TMZ)-based chemotherapy is a standard treatment for GBM, but development of chemoresistance poses a significant therapeutic challenge. Despite advances in understanding GBM biology, the mechanisms driving TMZ resistance remain unclear. Identifying vital molecular players involved in this resistance is...

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PMID: 40263417
DOI: 10.1038/s41598-025-92969-8

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