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Article

SOX4 inhibits GBM cell growth and induces G0/G1 cell cycle arrest through Akt-p53 axis

1 Nov 2014

Abstract excerpt

BACKGROUND: SOX4 is a transcription factor required for tissue development and differentiation in vertebrates. Overexpression of SOX4 has been reported in many cancers including glioblastoma multiforme (GBM), however, the underlying mechanism of actions has not been studied. In this study, we investigated the role of SOX4 in GBM. METHODS: Kaplan-Meier analysis was performed to assess the association between SOX4...

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PMID: 25366337
DOI: 10.1186/s12883-014-0207-y

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