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Article

The transcript ENST00000444125 of lncRNA LINC01503 promotes cancer stem cell properties of glioblastoma cells via reducing FBXW1 mediated GLI2 degradation.

Experimental cell research - 1 Mar 2022

Wei Pan, Jiang Jing, Xiao Ming, Zeng Mengfei, Liu Xingzhi, Zhao Baihao, Chen Fang

Abstract excerpt

LINC010503 is a novel oncogenic lncRNA in multiple cancers. In this study, we further explored the expression of LINC010503 transcripts and their regulations on the glioblastoma (GBM) stem cell (GSC) properties. LINC01503 transcription patterns in GBM and normal brain tissues were compared using RNA-seq data from Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA)-GBM. GBM cell lines (U251 and...

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PMID: 34990616
DOI: 10.1016/j.yexcr.2022.113009

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