Article

<i>MEOX2</i> homeobox gene promotes growth of malignant gliomas

2021-08-24

Abstract excerpt

Glioblastoma (GBM) is an aggressive tumor that frequently exhibits gain of chromosome 7, loss of chromosome 10 and aberrantly activated receptor tyrosine kinase signaling pathways. Here, we identify mesenchyme homeobox 2 (MEOX2) on chromosome 7 with increased expression in GBM as a salient oncogenic transcription factor. Specifically, we show that MEOX2 overexpression leads to increased ERK phosphorylation, and we...

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Literature Corpus work: 545ea21b-77dd-5b50-a682-c3025f2e3e97
DOI: 10.1101/2021.08.24.457477

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