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Sustained YAP1 activation induces DNA demethylation that promotes the development of hepatocellular carcinomas lacking driver gene mutations

2025-08-22

Abstract excerpt

<title>Abstract</title> <p>Recent advances in next-generation nucleotide sequencing have led to the identification of driver gene mutations (DGMs) in human cancers. However, a significant percentage of human malignancies without DGMs has been reported, and the mechanism of their tumorigenesis remains unclear. Here we show that sustained YAP1-TEAD activation induces the formation of DGM-negative hepatocellular car...

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Literature Corpus work
682c6220-72e6-51d7-95bf-c5b09f11731f
DOI
10.21203/rs.3.rs-7250110/v1
Open publication

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Sustained YAP1 activation induces DNA demethylation that promotes the development of hepatocellular carcinomas lacking driver gene mutationsDOI 10.21203/rs.3.rs-7250110/v1
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