Back to search

Article

CDT1-Mediated Regulation of DNA Damage Repair and Immune-Related Target Genes Underlies Hepatocellular Carcinoma Development

2025-12-02

Abstract excerpt

<title>Abstract</title> <p>Background Hepatocellular carcinoma (HCC) progression is tightly driven by genomic instability and dysregulated DNA damage repair (DDR) pathways. The replication licensing factor Chromatin Licensing and DNA Replication Factor 1 (CDT1) is frequently overexpressed in HCC tissues; however, the molecular mechanisms by which CDT1 coordinates DDR programs and modulates tumor immune microenvir...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3da888d0-125f-5326-b351-934617a8e34a
DOI
10.21203/rs.3.rs-8024873/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
CDT1-Mediated Regulation of DNA Damage Repair and Immune-Related Target Genes Underlies Hepatocellular Carcinoma DevelopmentDOI 10.21203/rs.3.rs-8024873/v1
CDT1 Is a Novel Prognostic and Predictive Biomarkers for Hepatocellular CarcinomaSemantic proximity
Elevated DNA Polymerase Delta 1 Expression Correlates With Tumor Progression and Immunosuppressive Tumor Microenvironment in Hepatocellular CarcinomaSemantic proximity
DNA Damage Repair Profiles Alteration Characterize a Hepatocellular Carcinoma Subtype With Unique Molecular and Clinicopathologic FeaturesSemantic proximity
DNA damage response-related signatures characterize the immune landscape and predict the prognosis of HCC via integrating single-cell and bulk RNA-sequencingSemantic proximity
Deciphering the immune modulation through deep transcriptomic profiling and therapeutic implications of DNA damage repair pattern in hepatocellular carcinomaSemantic proximity
Effect of Upregulated DNA Replication and Sister Chromatid Cohesion 1 Expression on Proliferation and Prognosis in Hepatocellular CarcinomaSemantic proximity
Sustained YAP1 activation induces DNA demethylation that promotes the development of hepatocellular carcinomas lacking driver gene mutationsSemantic proximity
Translationally Controlled Tumor Protein Induces Mitotic Defects and Chromosome Missegregation in Hepatocellular Carcinoma DevelopmentSemantic proximity
Construction of liver hepatocellular carcinoma-specific lncRNA-miRNA-mRNA network based on bioinformatics analysis.Semantic proximity
Integrated spatial and single cell transcriptomics identifies PRKDC as a dual prognostic biomarker and therapeutic target in hepatocellular carcinomaSemantic proximity
Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factor.Semantic proximity
Targeting POLR1A induces apoptosis and inhibits hepatocellular carcinoma proliferation through upregulation of IFI27 transcriptionSemantic proximity
Select a neighboring publication to make it the new centre.