Article

Suppression of YAP/TAZ molecular targets by epigenetic editing interferes with GBM growth and invasiveness

2026-03-15

Abstract excerpt

<h4>ABSTRACT</h4> Glioblastoma (GBM) is a highly aggressive brain tumor characterized by extensive heterogeneity, diffuse invasion, and recurrence despite multimodal therapy. Aberrant transcriptional programs driven by oncogenic signaling pathways sustain GBM growth, stemness, and therapy resistance, yet targeting individual molecular nodes has yielded limited clinical benefit. Here, we introduce a transcriptiona...

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Literature Corpus work: 36f282cb-7b7a-5165-bc07-238a25174dd3
DOI: 10.64898/2026.03.12.711340

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