YAP1 induces hepatocellular carcinoma via DNA demethylation rather than by canonical driver gene mutations.

doi:10.1038/s42003-026-10882-w

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Article

YAP1 induces hepatocellular carcinoma via DNA demethylation rather than by canonical driver gene mutations.

Communications biology - 17 Sept 2026

Kosaka Misaki, Okamoto-Uchida Yoshimi, Hirose Haruka, Nagaoka Yuya, Miyamura Norio, Kanai Akinori, Hatakeyama Daiki, Nakagawa Michiko, Nishio Miki, Maehama Tomohiko, Suzuki Akira, Suzuki Yutaka, Shimamura Teppei, Nishina Hiroshi

Abstract excerpt

Large-scale genome sequencing analyses have identified driver gene mutations (DGMs) in most cancers as well as their associated tumorigenic mechanisms. However, a small fraction of cancers are not positive for these canonical DGMs, leaving the mechanisms underpinning their formation a mystery. We hypothesized that canonical DGM-negative cancers might be driven by activation of the transcriptional coactivator YAP1...

Read the complete abstract on PubMed

Topics

Animals
Carcinoma, Hepatocellular
YAP-Signaling Proteins
Liver Neoplasms
Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adaptor Proteins, Signal Transducing

Mutation

Humans

Transcription Factors

DNA Demethylation

Gene Expression Regulation, Neoplastic

Proto-Oncogene Proteins

DNA Methylation

Cell Cycle Proteins

DNA-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 42754661
DOI: 10.1038/s42003-026-10882-w
PMCID: PMC13586348

Genes

YAP1
TET1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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