Article
Aging reduces the number and function of L-type calcium channels in the membrane of cardiac pacemaker cells
2022-06-26
Abstract excerpt
Every heartbeat is initiated by a spontaneous electrical signal generated inside the cardiac pacemaker. The generation of this electrical signal depends on the coordinated opening and closing of different ion channels, where voltage-gated L-type calcium channels play a central role. Despite the reliability of the pacemaker, all mammals experience a linear slowdown of the pacemaker rate with age. In humans, this sl...
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Identifiers and source
- Literature Corpus work
- 6809e159-e871-548f-8ae8-d3ae889a8cfe
- DOI
- 10.1101/2022.06.22.497267